The relationship of drug abuse to unexplained sudden death.
نویسندگان
چکیده
CONTEXT Forensic pathologists regularly investigate the deaths of individuals with a history of drug abuse. Autopsy, including toxicology testing, reveals no cause for death in a subset of this cohort. OBJECTIVE To determine whether deaths with an undetermined cause and manner of death are associated with a history of drug abuse. DESIGN Retrospective matched case-control study of 52 decedents whose cause of death remained undetermined following autopsy, matched 1:2 to a control group of living patients admitted for cholecystectomy according to age and date of death or procedure. RESULTS Individuals whose cause of death was undetermined were 5.3 times (95% confidence interval, 1.9-14.5) more likely to have a history of drug abuse than were patients with cholecystitis. CONCLUSIONS Decedents with a history of chronic drug abuse appear to be at an increased risk of dying by their chronic drug abuse, even in the absence of any anatomical or toxicologic finding at autopsy to account for death.
منابع مشابه
Unexplained sudden death and the likelihood of drug abuse.
The common history of drug abuse in adults with an undetermined cause of death has led us to hypothesize that chronic drug abuse increases the risk of sudden death. To begin evaluating this hypothesis, we conducted a retrospective case-control study of 61 decedents whose cause of death remained undetermined following autopsy matched one to one to a control group of pedestrians or passengers kil...
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عنوان ژورنال:
- Archives of pathology & laboratory medicine
دوره 132 12 شماره
صفحات -
تاریخ انتشار 2008